國家級人體生物資料庫整合平台

200026

分析Delta-like 1 Homolog （DLK1）在肝癌T細胞免疫監控所扮演的角色

Investigating the Role of Delta-like 1 Homolog （DLK1） in T Cell Immune Surveillance of Hepatocellular Carcinoma

200028

探討抑制刺蝟訊息途徑以增加肝細胞癌對於doxorubicin之敏感度的 角色–體外及體內之研究

To investigate the role of inhibition of sonic Hedgehog signaling pathway in increasing the sensitivity of doxorubicin in hepatocellular carcinoma-an in vitro and in vivo study

200029

肝細胞癌與肝纖維化病患血清中生物標記分析

Biomarkers analysis for hepatocellular carcinoma and liver fibrosis

200032

將BTK-ITK途徑作為標靶以克服肺癌治療的抗藥性以及抑制腦轉移的策略

Targeting the BTK-ITK axis as a potential therapeutic strategy for overcoming drug resistance and inhibiting brain metastasis in lung cancer

200001

LncRNA基因變異與肝癌的臨床表徵之研究

Study of the LncRNA genetic variants in hepatocellular carcinoma

200023

以具特異性的人類和B型肝炎病毒嵌合體DNA作為肝移植後肝癌復發的預測標記（2）

Specific HBV-human chimera DNA as a novel biomarker for predicting the outcome of HCC after transplantation （2）

200031

ASPM與 Wnt訊息傳導在肝癌幹原性與惡化以及相關奈米基因治療之開發

The role of ASPM-Wnt signaling in hepatoma cancer stemness and progression and the development of the related nano- and gene-therapy

200045

肺腺癌中血管擬態的基因表現

Gene expressions of vasculogenic mimicry in lung adenocarcinoma

200021

探討肺癌多體（或組）學標記的臨床意義

Exploring the clinical significance of multi-omic markers of lung cancer

200048

探討胺基酸訊息傳遞路徑之第-GATOR複合體/mTOR複合體在肝癌形成之研究

To study amino-acid-dependent GATORC1/mTORC1 signaling in the development of hepatocellular carcinoma

200053

CAR蛋白在肺癌細胞之角色與流感病毒感染造成肺腫瘤形 成機制之探討

The role of CAR expression in human lung cancer and analysis the mechanism of respiratory associated virus infection in lung epithelial cell tumorigenesis

200025

利用血液之生物標誌來篩檢出肝癌病患-根據台灣國家級人體生物資 料庫整合平台樣本之研究

Using circulating biomarkers to identify the patients with hepatocellular carcinoma-based on the samples from National Biobank Consortium of Taiwan

200049

探討大腸直腸癌、肺癌與肝癌之基因與分子機轉研究

Study the genes and molecular mechanisms affecting of colorectal cancer, lung cancer and liver cancer

200058

Collagen XVII在肺癌幹細胞中多功能基因表現與代謝重整之角色及 相關機轉探討

The Role of Collagen XVII in the Pluripotent Gene Expression and Metabolic Reprogramming of Lung Cancer Stem Cells

200024

表皮生長因子接受器基因突變之肺腺癌合併腦轉移的病人其免疫生物標記與病理表現之關聯性

Immune biomarkers and pathology correlation in lung adenocarcinoma patients with epidermal growth factor receptor gene mutation and brain metastasis

200035

200038

整合台灣兒童癌症臨床治療及分子診斷

Integration of treatment strategies and molecular diagnosis for childhood cancers in Taiwan

200054

局部及侵犯性肝細胞癌之免疫標記

Immune landmark in local limited HCC and advanced HCC

200004

利用可視化檢測轉座酶易接近的染色質（ATAC-see/seq）技術建立預測RA 患者使用最佳生物製劑之模式

Using ATAC-see/seq to establish the pre-screen model to determine the best biological agents for rheumatoid arthritis patients

200030

慢性腎病引發加速動脈硬化疾病之機制：探討巨細胞病毒 感染及免疫老化現 象為中介因子

Novel mechanism of accelerated atherosclerosis in renal failure: roles of immunosenescence and cytomegalovirus infection

200050

腳趾骨腕骨併聯症候群的家族基因研究及基因功能分析

The novel gene/variant study of tarsal-carpal coalition syndrome from a family

200051

以患者尿液菌相基因分析其骨盆腔疼痛症候群之影響機制

Investigating the mechanism of chronic pelvic pain syndrome by patients’ microbiota composition in urine

200052

腎臟疾病之尿液外泌體中miRNA鑑定與分析

Identification and Analysis of Urinary Exosomal miRNA in Patients with Kidney Disease

200059

NKX6.1基因高度甲基化與大腸直腸癌抗藥性之關聯性研究 -用藥指 引生物指標與其生理意義

Study on the association between NKX6.1 hypermethylation and chemoresistance in colorectal cancer - biomarker for therapy selection and its physiological role

200061

必需性微量元素和慢性腎臟疾病：心血管和腎臟疾病預後之關聯性研究

Essential trace elements and chronic kidney disease: association with cardiovascular and kidney outcomes

200063

右心室出口處心律不整的泛基因體掃描遺傳相關研究

Genomewide Association Study of Right Ventricular Outflow Tract Ventricular Arrhythmia

200060

磺胺劑引起肝傷害之藥物基因學研究

Pharmacogenetic study of sulfonamide-induced liver injury

200014

探討台灣冠心症患者的家族性高膽固醇血症基因型

Familial Hypercholesterolemia Genotype in Taiwanese Patients with Coronary Heart Disease

200037

IRGM調控之細胞自噬作用與腸道細菌叢間的交互作用對於非酒精性脂肪肝疾病的影響

The Interaction of IRGM-Mediated Autophagy and Gut Microbiota in Nonalcoholic Fatty Liver Disease

200036

腫瘤纖維母細胞分子改變對頭頸癌抗藥性之研究

Study of Molecular alteration in cancer-associated fibroblasts for induction of drug resistance of head and neck cancer

200043

內源性半乳糖凝集素-3、NLRP3發炎體與自噬作用對IgA腎病變致病機制之調控

The regulation of endogenous galectin-3、NLRP3 inflammasome and autophagy in the pathogenesis of IgA nephropathy

200055

Toll-Like Receptor 2與IL-32在系統性紅斑狼瘡中表達之關聯性與 其機轉

The relationship between TLR2 and IL-32 expression in systemic lupus erythematosus and its mechanism

200003

KLF16於胃癌之角色及機制探討

The role of KLF16 and its carcinogenic mechanism in gastric cancer

200039

探討以Myc/PD-L1/Akt作為治療惡性腦癌標靶之轉譯研究

A translational investigation of the role of Myc/PD-L1/Akt axis as a therapeutic target for treating glioblastoma multiforme

200047

建立自體免疫腎炎病人之基因資料庫與個人化醫療

Establishment of genomics database of autoimmune nephritis for personalized medicine

200056

系統性紅斑性狼瘡於CARD14、RIMS2基因表現與IFN轉錄因子表現之相關及機制性探討

The correlation and mechanism study of functional gene, CARD14 and RIMS2, with IFN transcription factor in SLE

200011

透過分析mRNA微列陣資料庫研究口腔癌的代謝路徑

To identify metabolic pathway associated with oral cancer progression by analyzing mRNA database

200033

用於誘導頭頸癌細胞染色體不穩定的 PLK 抑製劑的藥物篩選

Drug Screen of PLK inhibitors for inducing chromosomal instability on head and neck cancer cells

200042

探討與甲狀腺癌診斷預後和抗藥性相關之生物標記

Potential bio-markers in predict prognosis and drug resistance of thyroid cancer

200069

乳癌ER、PR、HER-2、Ki-67的AI model

AI model of ER、PR、HER-2、Ki-67 in breast cancer

200006

提升口腔癌前病變及口腔癌診斷率之整合性研究

An integrated study for improvement of diagnostic efficiency for oral precancer and cancer

200010

探討與鑑定上泌尿道泌尿上皮癌中好發的基因變異:在病理生理上的 應用及臨床意義

Identification and characterization of the frequent genetic alternations in upper tract urothelial carcinoma : the pathophysiological implication and clinical significance

200016

人類腸胃道腫瘤：整合影像形態學與代謝體精準醫學研究

Precision medicine for human gastric and colon cancers: Integrated metabolomics and morphomics imaging analysis

200017

多型性膠質母細胞瘤之免疫療法預後評估與病程監測平台建構

Establishing a screening platform to evaluate the prognosis and progression for glioblastoma multiforme （GBM） treated with immunotherapeutic strategies

200022

探討胰臟癌多體（或組）學標記的臨床意義

Exploring the clinical significance of multi-omic markers of pancreatic cancer

200067

自我調控的STAT訊號在食道鱗狀上皮癌的預後診斷

Interaction between IL-13 and CCL5 at Esophageal Squamous Cell Carcinoma: Possible Mechanism of Tumor Progression

200008

發炎體基因多形性與砷暴露基因-環境交互作用對腎細胞癌化 之影響及機制探討

Effects of gene-environment interaction of inflammasome gene polymorphisms and arsenic exposure on renal cell carcinogenesis and its mechanism

200044

以IgA1 O-聯結醣基為標靶開發IgA腎病變之診斷試劑重塑臨床評估之準則

Targeting O-glycans of IgA1 to develop diagnostic reagents for IgA nephropathy and reshape its clinical assessment protocol

200002

miR-302調控MST1及PDX-1路徑對抗糖脂毒性導致β細胞老化與凋亡之機制探討

Investigating the mechanisms of miR-302 protects against glucolipotoxicity-induced β-cell senescence and apoptosis by regulation of MST1 and PDX-1 pathway

200018

利用細胞內鉑金含量預測泌尿上皮癌患者接受前導性化療之療效

Using intracellular platinum content to predict outcome of urothelial carcinoma patients with neoadjuvant cisplatin treatment

200027

尋找與低度風險攝護腺癌惡化有關之基因及路徑—一個預防攝 護腺癌之新策略

Identify genes/pathways responsible for progression from low risk to higher risk prostate cancer—A new strategy for prostate cancer prevention

200012

比較腹腔鏡手術或機器手臂輔助手術治療經術前同步化放療之中低位直腸癌的前瞻性隨機對照試驗

A Randomized Prospective Controlled Clinical Trial Regarding the Surgical Outcomes of Robotic Approach versus Laparoscopic for the Surgery of Middle or Low Rectal Cancer After Preoperative Chemoradiation

200040

三陰性乳癌與高級別漿液性卵巢癌 p53, IGF-1R, PR 表現互相擷抗 之研究

Antagonization between IGF-1R and p53 or PR in triple-negative breast cancer and ovarian high-grade serous carcinoma

200065

探討非 BRCA突變型卵巢癌組織中 miRNA profile與 BRCA1 表現的關聯性

Investigation of potential miRNAs profiles linking to reduced BRCA1 expression in ovarian cancer patients without genomic mutations.

200015

探討草本芳香類奈米製劑干擾腫瘤生成及上皮細胞間質轉化對抑制尿路上皮癌的效用

To investigate the roles of herbal aromatic substances nanoparticles （HAS NPs） on inhibition of tumorigenesis and epithelial-mesenchymal transition （EMT） on human urothelial carcinoma （UC） cells

200041

探討體液中微型RNA在 泌尿道上皮癌中的功能及應用

Exploration of the functions and applications of miRNAs in urothelial carcinoma

200064

CD44及ALDH1在卵巢癌抗細胞凋亡所扮演的角色:著重於DNA修復的能力

The role of CD44 and ALDH1 on anti-apoptosis of ovarian cancer cells: focus on the DNA repairing capability

200046

探討MBNL3對於卵巢癌生長及轉移的影響及分子機制（第一期）

To investigate the effect of MBNL3 on the growth and metastasis of ovarian cancer and its molecular mechanism （Phase I）

200057

探討神經內分泌分化相關長鏈非轉譯碼RNA在賀爾蒙不依賴復發型 攝護腺癌中的重要性: 找尋能成為新的癌症標誌或治療標靶之長鏈非轉譯碼RNA-第二期計畫

Study neuroendocrine differentiation-related lincRNAs in castration-resistant relapsed prostate cancer: Implication in prognosis and therapy-phase II

200070

PML 在乳腺癌 發病機理作用

Role of PML in the Pathogenesis of Breast Cancer

210073

利用全基因體定序及轉錄體定序分析偵測呼吸道常見微生物菌叢與肺癌進程之相關性

Detection of airway commensal microbiome in association with lung cancer promotion by whole genome and whole-transcriptome sequencing analyses

210072

使用血漿癌蛋白體進行肺癌早期篩檢之臨床應用評估計畫

Clinical Utility of Plasma Cancer Proteomic Profile for Early Detecting Lung Cancer

200009

三陰性乳癌細胞中LGR5蛋白參與侵襲與轉移的相關機制探討以及利 用磁性輔助配適體快速篩選平台開發抑制LGR5活性之標靶化療配適體

To investigate the malignant role of LGR5 in triple-negative breast cancer and develop LGR5 targeted chemotherapy aptamer by Magnetic-Assisted Rapid Aptamer Selection （MARAS）

200066

EB病毒感染及變異基因與乳癌病人預後相關研究的驗證

Study and Validation for Epstein-Barr virus infection, genes mutation and outcome in breast cancer patients

200005

NCAPG過度表現於大腸直腸癌之臨床意義及致癌機轉

Clinical impact and carcinogenic mechanism of NCAPG overexpression in colorectal cancer

200007

表異質基因調控酵素及其抑制劑在個人化乳癌治療上的角色及應用

The role of epigenetic modifying enzymes and inhibitors in personalized therapy of breast cancer patients

200013

探討ATMIN對於微星粒穩定大腸直腸癌的分子機轉及臨床意義

Investigation of molecular mechanism and clinical significance of ATMIN （ataxia telangiectasia mutated interactor） in colorectal cancer with MSS （microsatellite stable） status

200019

探討台灣年輕女性三陰性乳癌多體（或組）學標記的臨床意義

Exploring the clinical significance of multi-omic markers of young Taiwanese women with triple-negative breast cancer

200020

探討黏液性結直腸腺癌多體（或組）學標記的臨床意義

Exploring the clinical significance of multi-omic markers of mucinous colorectal adenocarcinoma

200034

研究BTK/HER2信號通路在HER2陽性乳腺癌生物特性角色: 調控T細胞的效應及逆轉賀癌平抗藥性的分子機制

Investigating the role of BTK/HER2 signaling as a therapeutic target for restoration of T cell function and reversal of Trastuzumab resistance in HER2+ Breast cancer

200062

研究巨細胞病毒US28基因型與大腸直腸癌病人預後之關連性

Study of the association among HCMV US28 genotypes and outcome of colorectal patients

210071

以RNA定序預測三陰性乳癌患者的治療反應並探討免疫檢查點抑制劑療法的抗藥機制

Using RNA sequencing to predict the therapeutic response and explore the resistance mechanism for immune checkpoint blockade therapy in patients with triple-negative breast cancer

73

210074

蔡璧合

義守大學;醫學系

p73活化劑於不同構型p53突變之頭頸部鱗狀細胞癌所造成

抑制癌作用評估

Evaluation of the anti-cancer effect of p73

activator on head and neck squamous cell carcinoma

with different conformation of p53 mutations

20

20220107

74

210075

翁菁甫

新竹國泰綜合醫院;呼吸胸腔科

SLC7A5作為肺癌治療標靶併藥物篩選平台及臨床預後研究

SLC7A5 in lung cancer as therapeutic target and drug screen platform with analysis of clinical prognostic relevance

100